My picks:
Civilization 1 - too dated
Icewind Dale series - while I love the setting, I consider those games linear, combat heavy slogs with little plot. Would rather play BG or PST instead.
Platformers - played Prehistoric, Lost Vikings, Lion King, Contra and Prince of Persia a lot as a kid, but don't enjoy them anymore.
Unreal - replayed the game last year with a high res texture pack and it was a slog, I do not think I am ever going to play it again. OTOH I still play Doom and Quake with source ports.
Unreal Tournament and Quake 3 Arena against bots - I am never going to play them again, unless I find human opponents.
World of Warcraft - I played until around level 65 on private servers and got bored. I must admit, however, that seeing locations from Warcraft 1 and 2 up close was a treat at that time. IMO Warcraft lore is beyond saving by now. I do not think I am ever going to play any MMOs again.
Betrayal at Krondor - too dated.
Gothic 1 - it was fun to play it once, but I do not see myself playing it again. Never understood the cult following it has on Codex. Gothic 2 played as a mage was a slog. I may, however, revisit it one day as a melee character.
Kotor 1 - feels cheesy nowdays, not sure why it was so successful back in the day
First two Total War games - too dated
Bioshock - would rather replay System Shock 2
Simcity 1 - too dated
Age of Empires 1 - too dated. I might, however, be tempted to replay Warcraft 1 one day for lore
Incredible Machine - don't enjoy puzzle games anymore